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Crizotinib Side Effects

Common Side Effects

Crizotinib has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common crizotinib side effects included:
  • Vision problems, including double vision, flashes of light, blurred vision, and "floaters" -- in up to 64 percent of people
  • Nausea -- up to 57 percent
  • Vomiting -- up to 45 percent
  • Constipation -- up to 38 percent
  • Swelling due to fluid retention (edema) -- up to 38 percent
  • Fatigue -- up to 31 percent
  • Decreased appetite -- up to 27 percent
  • Dizziness -- up to 24 percent
  • Burning, tingling, and numbing sensations of the skin -- up to 23 percent
  • Shortness of breath -- up to 22 percent
  • Coughing -- up to 21 percent
  • Heartburn or indigestion -- up to 20 percent.
Other common reactions, occurring in 4 to 20 percent of people, included:
  • Symptoms of the common cold, such as congestion, runny nose, and sore throat
  • Abdominal (stomach) pain
  • Rash
  • Increase in liver enzymes
  • Headaches
  • Changes in sense of taste
  • Chest pain
  • Fever
  • Insomnia
  • Mouth pain, sores, and inflammation
  • Joint pain
  • Back pain
  • Low heart rate
  • Low white blood cell counts.

Final Thoughts

You may experience some or none of the crizotinib side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking this medication or if something "just does not seem right." While it may not be related to crizotinib, your healthcare provider will be able to diagnose and treat the problem.
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