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Drug Interactions

Crizotinib may react with a number of other medicines (see Drug Interactions With Crizotinib).

What If I Overdose on This Medicine?

It is unclear what exactly to expect from an overdose with this medicine. Seek immediate medical attention if you or someone else may have taken too much.
(Click Xalkori Overdose for more information.)

What If I Miss a Dose of Crizotinib?

If you miss a dose of crizotinib, take it as soon as you remember. If it is less than six hours until your next dose, however, skip the missed dose and continue with your regular schedule. Do not take a double dose.

How Does It Work?

Tyrosine kinases are proteins found in the body that help regulate cell function, including cell growth. Crizotinib belongs to a group of medicines known as tyrosine kinase inhibitors. It works by blocking the action of tyrosine kinases, including a specific tyrosine kinase known as anaplastic lymphoma kinase (ALK). When ALK does not function properly, it causes cancer cells to grow. By blocking ALK, crizotinib can slow down the growth of cancer cells and shrink existing tumors.

Clinical Effects

Crizotinib was shown to be effective in clinical studies that included people with late-stage, non-small cell lung cancer who had the abnormal ALK gene. Most people had been previously treated for their cancer. In these studies, 50 to 61 percent of people, on average, experienced complete or partial cancer shrinkage during crizotinib treatment.
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Crizotinib Drug Information

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