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Cometriq Drug Interactions

Cometriq Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Cometriq is combined with any of the drugs listed above.
 
CYP 3A4 Inducer Medications
The liver breaks down Cometriq using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Cometriq with one of these drugs may decrease the level of Cometriq in your body, potentially making it less effective.
 
It is generally recommended that Cometriq not be combined with medications that are strong CYP 3A4 inducers, if at all possible. If you need to take a strong CYP 3A4 inducer medicine during Cometriq treatment, your healthcare provider may choose to increase your Cometriq dosage by 40 mg, provided your dose does not exceed 180 mg a day. If you stop taking the CYP 3A4 inducer, you will resume your usual Cometriq dose two to three days later.
 
CYP 3A4 Inhibitor Medications
The liver breaks down Cometriq using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Cometriq with one of these drugs may increase the level of Cometriq in your body, potentially increasing your risk for side effects.
 
It is generally recommended that Cometriq not be combined with strong CYP 3A4 inhibitors. If you must take a CYP 3A4 inhibitor, your healthcare provider may choose to decrease your Cometriq dose by 40 mg, provided your dose is no lower than 60 mg a day. If you stop taking the CYP 3A4 inhibitor, you will resume your usual Cometriq dose two to three days later.
 

Final Thoughts

It is possible that not all Cometriq drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
 
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