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What Is Clofarabine Used For?

How Does This Medicine Work?

Clofarabine works to treat leukemia in a couple of different ways. The drug enters cells, where it prevents DNA from replicating. Because DNA replication is necessary for cancer cells to divide, clofarabine can block the growth of the leukemia cells.

Clofarabine also damages the mitochondrial membrane, which is an important part of the cell that provides it with usable energy. By damaging this vital cell structure, the medication can cause leukemia cells to die.
 

Is Clofarabine Used in Adults?

Clofarabine has not been adequately studied in adults, including older adults. It is not approved for use in individuals older than age 21. In one study, adults with blood cancers did not tolerate the usual recommended clofarabine dosage for children. However, the drug may be used "off-label" (in an approved fashion) in adults.
 

What About Other Off-Label Uses for Clofarabine?

On occasion, your healthcare provider may recommend this medicine for treating something other than the conditions discussed in this article. This is called an "off-label" use. Possible off-label uses for clofarabine include treatment of the following conditions:
 
  • Acute myelocytic leukemia
  • Myelodysplastic syndrome
  • Chronic myeloid leukemia.
 
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Clofarabine Medication Information

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