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Clofarabine Side Effects

Common Side Effects

Clofarabine has been studied extensively in clinical trials. In these studies, the side effects that occurred in children who received the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common clofarabine side effects included:
  • Low white blood cells, which could increase the risk for infections (see Chemotherapy and Infections) -- in up to 87.7 percent of children
  • Anemia (low red blood cells) -- up to 83.3 percent (see Chemotherapy and Anemia)
  • A decrease in platelets, which could increase the risk for bleeding (see Blood Clotting Problems and Chemotherapy) -- up to 80.7 percent
  • Vomiting -- up to 78.3 percent
  • Nausea -- up to 73 percent
  • Diarrhea -- up to 55.7 percent
  • Headache -- up to 42.6 percent
  • Itching -- up to 42.6 percent
  • Fever -- up to 39.1 percent
  • Rash -- up to 38.3 percent.
Other common side effects, occurring in 5.2 percent to 34.8 percent of people, included:
  • Increased heart rate (tachycardia)
  • Abdominal (stomach) pain
  • Chills
  • Fatigue
  • Loss of appetite
  • Nosebleeds
  • Small red or purple spots on the skin
  • Low blood pressure (hypotension)
  • Anxiety
  • Inflammation, sores, or ulcers in the mouth or throat  (see Mouth and Gum Problems During Chemotherapy)
  • Tingling, redness, or dryness of the skin on the hands or feet
  • Sudden warmth and redness of the face, neck, or chest area (flushing)
  • Bleeding of the gums
  • General pain
  • Back, arm, and leg pain
  • Muscle, joint, and bone pain
  • Swelling of the arms, hands, legs, ankles, feet, or other body areas
  • Infections
  • Lack of strength and energy
  • Fungal infection in the mouth
  • Lethargy and drowsiness
  • Blood in the urine
  • Breathing problems, such as shortness of breath
  • Chest pain or painful breathing
  • High blood pressure (hypertension)
  • Rectal pain
  • Irritability and agitation
  • Yellowing of the skin or whites of the eyes (jaundice).
A Dose of Reassurance for Parents of Picky Eaters

Clofarabine Medication Information

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