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Clofarabine

Clinical Effects of Clofarabine

Clofarabine has been studied in clinical trials. In one of these trials, 61 children with acute lymphoblastic leukemia who had failed treatment with at least two previous treatment regimens were given the medication. Twelve of the children (19.7 percent) went into remission. The median length of remission was 10.4 months (the median is the middle number, meaning half of the children were in remission for less than 10.4 months, while half were in remission for more than 10.4 months.)
 
In addition, six children (9.8 percent) had a partial response to clofarabine. A partial response means there are no leukemia cells in the bloodstream and fewer cancer cells in the bone marrow.
 
Clinical studies did not look at whether the medication could help children with ALL live longer. It is also unknown if clofarabine can help cure ALL.
 

When and How to Use This Medicine

Some general considerations to keep in mind during treatment with clofarabine include the following:
 
  • This medication comes in the form of a liquid that is given as a slow injection into a vein (an intravenous, or IV, infusion). It is usually given once a day for five days in a row every two to six weeks.
 
  • It will take about two hours to receive each clofarabine dose.
 
  • Clofarabine infusions are normally given by a healthcare provider in a healthcare setting, such as a hospital or clinic, where you can be closely monitored.
 
  • You will receive IV fluids and other medications throughout each five-day treatment cycle to help reduce the risk for certain clofarabine side effects.
 
  • Your healthcare provider may also recommend other medicines, such as medications for nausea and vomiting, steroids, or antibiotics, to help reduce or prevent side effects.
 
  • You should drink plenty of fluids during treatment to help stay hydrated.
 
  • Let your healthcare provider know right away if you feel anxious during the clofarabine infusion. He or she can slow down the infusion, which may help reduce the anxiety.
 
  • For the medication to work properly, it must be used as prescribed. It is important to keep all of your appointments to receive clofarabine.
 
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Clofarabine Medication Information

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