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Chlorambucil Side Effects

Some of the possible side effects of chlorambucil can include nausea, vomiting, and diarrhea. This prescription medication can also cause low levels of red or white blood cells and platelets. This can increase your risk for infections, anemia, or other problems. Seek immediate medical attention if you develop unusual bleeding, fever, or confusion.

An Introduction to Side Effects of Chlorambucil

Just like any medicine, chlorambucil (Leukeran®) can cause side effects. As with other chemotherapy medicines, the side effects can be significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with chlorambucil. Your healthcare provider can discuss a more complete list with you.)

Serious Chlorambucil Side Effects

Some side effects of chlorambucil are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • Rash
    • Hives
    • Itching
    • Swelling of the mouth, tongue, face, lips, or throat
    • Difficulty breathing or swallowing
    • Fever
    • Chills
    • Aches and pains
    • Sore throat
    • Cough
    • Painful urination
  • Any unusual bleeding or bruising
  • Dark, tarry, or bloody stools
  • Signs of anemia, such as extreme tiredness, dizziness, or pale skin
  • Unusual muscle movements, such as twitching, jerking, or tremors
  • Muscle weakness or difficulty walking or moving
  • Agitation or confusion
  • Hallucinations (seeing or hearing things that are not really there)
  • Seizures
  • Severe mouth sores (see Mouth and Gum Problems During Chemotherapy)
  • Shortness of breath or new or worsening cough
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Upper-right abdominal (stomach) pain
  • Signs of new tumors or cancers, such as:
    • Changes in the size or color of moles
    • Skin sores that do not heal
    • Unusual lumps or growths
  • Numbness, tingling, or pricking sensations, especially of the hands or feet
  • Severe or persistent vomiting or diarrhea
  • Missed menstrual periods.


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Chlorambucil Drug Information

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