Your body may retain fluid when you are undergoing chemotherapy treatment. This may be due to hormonal changes from your therapy, the chemotherapy drugs themselves, or because of your cancer. Check with your healthcare provider or nurse if you notice swelling or puffiness in your face, hands, feet, or abdomen. You may need to avoid table salt and foods that contain high amounts of salt. If you experience a severe case of fluid retention during chemotherapy, your healthcare provider may prescribe a diuretic (a medicine to help your body get rid of excess fluids).