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What Is Zofran?
Zofran® (ondansetron hydrochloride) is a prescription medicine that has been approved to prevent nausea and vomiting associated with:
- Chemotherapy
- Radiation therapy
- Surgery.
It's also important to know what Zofran isn't approved for. This medication is not intended to treat nausea or vomiting that is already occurring. It is much easier to prevent nausea and vomiting than to treat it once it starts.
This drug is generally well tolerated. However, as with any medicine, side effects are possible. In clinical trials, common side effects of Zofran included:
- Headache
- Tiredness (fatigue) or a general ill feeling
- Constipation.
(Click Zofran for more information about this drug, including how to take it, generic availability, and what to discuss with your healthcare provider.)
Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD



