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Precautions and Warnings With Cabazitaxel

Before taking cabazitaxel, it's important to understand that this medication can cause problems for some people, such as an increased risk for bleeding problems, electrolyte imbalances, and severe dehydration. Also, safety precautions to be aware of with cabazitaxel include warnings of potential drug interactions and allergic reactions. You may not be able to use this drug if you have low blood counts, liver disease, or kidney disease.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving cabazitaxel (Jevtana®) if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • Low blood counts
  • Any allergies, including to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Cabazitaxel Precautions and Warnings

Some warnings and precautions to be aware of prior to receiving cabazitaxel include the following:
 
  • This medication can decrease the bone marrow's ability to produce blood cells. This can result in anemia and other serious conditions. Because your immune system depends on certain blood cells, you may be more susceptible to infections while using cabazitaxel (see Chemotherapy and Infections). You may also have a higher risk for bleeding (see Blood Clotting Problems and Chemotherapy).
You will need regular blood tests during treatment to make sure your blood counts are not too low. These side effects can be quite serious; some deaths have occurred.
  • There is a small risk for death while using cabazitaxel, mostly due to dangerous infections caused by low levels of white blood cells.
     
  • Cabazitaxel can cause serious allergic reactions. To prevent this, you should receive a corticosteroid, an antihistamine, and an H2 antagonist intravenously at least 30 minutes before each cabazitaxel infusion. Your healthcare provider may also give you antinausea medications.
     
  • This medication can cause severe nausea, vomiting, and diarrhea. This can result in dangerous dehydration and serious electrolyte imbalances. Deaths have occurred.
     
  • In clinical trials, there were a few reports of kidney failure (renal failure), mostly due to extremely severe widespread infections, dehydration, or the blockage of urine flow in the kidneys. Your healthcare provider should monitor your kidney function during treatment.
     
  • People ages 65 years old and older are more likely to experience severe side effects of cabazitaxel.
     
  • The liver breaks down (metabolizes) cabazitaxel. In people with liver disease, the drug may accumulate in the body, causing serious side effects.
     
  • Cabazitaxel can react with other medications (see Drug Interactions With Cabazitaxel).
     
  • This product is considered a pregnancy Category D medication. This means that it is probably not safe for use during pregnancy. Talk to your healthcare provider about the risks and benefits of using the drug while pregnant (see Jevtana and Pregnancy).
     
  • It is not known if cabazitaxel passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to receiving the drug (see Jevtana and Breastfeeding).
     
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Cabazitaxel Drug Information

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