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What If I Receive an Overdose of Cabazitaxel?

An overdose of this medication could be dangerous, as it may cause dangerously low blood counts (see Jevtana Overdose for more information).

What Should I Do If I Miss a Dose?

If you fail to receive a dose of cabazitaxel on schedule, contact your healthcare provider to set up an appointment for your next dose right away.

How Does Cabazitaxel Work?

Cabazitaxel belongs to a group of medications called taxanes. Taxanes stop cancer cells from growing and multiplying by interfering with certain structures in the cell.
Although cabazitaxel can kill both healthy and cancerous cells, it has a greater effect on cells that are multiplying rapidly. Generally, cancer cells multiply more rapidly than healthy cells and are, therefore, more affected by cabazitaxel.

Clinical Effects

One study looked at using cabazitaxel plus prednisone to treat metastatic prostate cancer (prostate cancer that has spread to other parts of the body) in people who had been unsuccessfully treated with certain other types of chemotherapy.
People were given either cabazitaxel plus prednisone or mitoxantrone (Novantrone®) plus prednisone. Compared to the mitoxantrone/prednisone combination, the Jevtana/prednisone combination increased the average survival time from 12.7 months to 15.1 months.

When and How to Receive Cabazitaxel

Some general considerations to keep in mind during treatment with cabazitaxel include the following:
  • This medication is administered intravenously (by IV) once every three weeks. It is combined with oral prednisone tablets, which are taken every day during the treatment period, even between Jevtana infusions.
  • You should be given medications (such as a corticosteroid, an antihistamine, and an H2 antagonist) before each dose of cabazitaxel to help prevent allergic reactions.
  • The IV is given over a period of one hour.
  • For cabazitaxel to work properly, it must be taken as prescribed.
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