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What Is Busulfan Injection Used For?

How Does It Work?

Busulfan injection is part of a group of medications called alkylating agents. In general, alkylating agents work by causing strands of DNA to bond to each other and become linked (this is known as "cross-linking"). The linked strands cannot uncoil and separate, which is necessary for the DNA to replicate. Because DNA replication is essential for cells to grow and multiply, busulfan injection may prevent cancer cells from growing and multiplying.

Can Children Use Busulfan Injection?

Busulfan injection is not approved for use in children, as it has not been adequately studied in this age group. However, this does not mean the medicine cannot be used in children. In fact, it may be used off-label prior to a stem cell transplant in a child. Talk with your child's healthcare provider about the particular benefits and risks of giving this medicine to children.

Is It Safe for Older Adults?

Older adults can be treated with busulfan injection. However, they may be more sensitive to the effects of the drug and may, therefore, need to be monitored more closely.

What About Off-Label Busulfan Injection Uses?

On occasion, your healthcare provider may recommend this medicine for something other than the uses discussed in this article. This is called an "off-label" use. Busulfan injection may be used off-label to prepare the body for stem cell transplant in people with other types of leukemia, lymphoma, or multiple myeloma.
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Busulfan Injection Information

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