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What Is Busulfan Injection Used For?

Busulfan Injection Use for the Treatment of CML

There are several different treatment options for people with CML, including:
Stem cell transplant is the only treatment that can be used to cure CML. During this procedure, a person is given stem cells through a slow injection into a vein (an infusion). The stem cells settle into the bone marrow and replace the body's blood cells.
Normally, conditioning regimens are given to prepare the body prior to a stem cell transplant. Conditioning regimens use high doses of chemotherapy to destroy cancer cells. These high doses also destroy the body's stem cells, which are then replaced by the stem cell transplant. Conditioning regimens also act to deplete the body's immune system, which can help prevent graft rejection.
A stem cell transplant can be allogeneic or autologous. In an autologous stem cell transplant, stem cells are removed from the person being treated and then given back to that same person after they have received high-dose chemotherapy. Essentially, a person is acting as their own donor. Obviously, one disadvantage of an autologous stem cell transplant is that if cancer cells were removed with the stem cells, they could then be reintroduced into the body during the transplant.
In contrast, in an allogeneic stem cell transplant, stem cells are provided by a carefully matched donor. These donated stem cells will be free of cancer cells. However, even when recipients and donors are carefully matched, there is still the possibility that the recipient's body may reject the donated stem cells. This is known as graft rejection. Further, the immune cells from the donor may attack the recipient's body after the transplant (known as graft-versus-host disease).
Stem cells can come from bone marrow (bone marrow transplant), the blood (peripheral blood stem cell transplant), or umbilical cord blood from a newborn (cord blood transplant). All of these transplants are still called stem cell transplants. In the past, the vast majority of stem cell transplants were bone marrow transplants. However, today peripheral blood stem cell transplants are commonly used. Cord blood transplants are rarely used in adults because they do not normally contain enough stem cells to be effective.
Busulfan injection is used as part of a conditioning regimen that also includes cyclophosphamide. It is specifically approved for use before an allogeneic stem cell transplant.
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Busulfan Injection Information

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