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Drug Interactions With Busulfan Injection

CYP 3A4 Inducer Medications
The liver breaks down busulfan injection using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining busulfan injection with one of these drugs may decrease the level of busulfan injection in your body, possibly making it less effective. Your healthcare provider may need to monitor you more closely if you combine these medications.
 
CYP 3A4 Inhibitor Medications
The liver breaks down busulfan injection using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining busulfan injection with one of these drugs may increase the level of busulfan injection in your body, increasing your risk for side effects. Your healthcare provider may monitor you more closely if you use these medications together.
 
Echinacea
Echinacea could potentially decrease the effectiveness of busulfan injection. Talk to your healthcare provider before taking these products together.
 
Ifosfamide
Combining busulfan injection with ifosfamide may increase your risk for a potentially serious bladder condition known as hemorrhagic cystitis. Hemorrhagic cystitis is associated with bladder irritation and blood in the urine. Your healthcare provider may choose to monitor you more closely, or give you other medicines to prevent hemorrhagic cystitis if you take ifosfamide during busulfan injection treatment.
 
Itraconazole
Itraconazole may increase blood levels of busulfan injection, which could increase your risk for side effects. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. It is generally recommended that people receiving chemotherapy not receive live vaccines. This is because chemotherapy medicines, including busulfan injection, may increase your risk for infections, and you could become infected with the virus or bacteria used to make a live vaccine. Also, live vaccines may be less effective during chemotherapy treatment. Talk to your healthcare provider before getting a vaccination while you are using this drug.
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Busulfan Injection Information

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