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Busulfan Injection Side Effects

If you experience unusual bleeding, chest pain, or fever while using busulfan injection, contact your healthcare provider right away. Clinical studies have shown that most people using this chemotherapy drug will develop some type of reaction, such as nausea, vomiting, or loss of appetite. However, because side effects of busulfan injection may be significant, seek medical attention if you develop anything that just does not seem right.

An Introduction to Side Effects of Busulfan Injection

As with any chemotherapy medicine, busulfan injection (Busulfex®) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
 
(This article covers many, but not all, of the possible side effects with busulfan injection. Your healthcare provider can discuss a more complete list with you.)
 

Serious Busulfan Injection Side Effects

Some side effects of busulfan injection are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Signs of an infection, such as:
     
 
  • Signs of anemia, such as:
     
    • Weakness
    • Unusual fatigue
    • Pale skin
    • Shortness of breath
    • Dizziness
 
  • Any unusual bleeding or bruising
  • Black, tarry, or bloody stools
  • Vomiting blood
  • Pain, redness, or swelling at the injection site
  • Redness, swelling, or blistering of the skin
  • Pain and swelling in one leg and not the other
  • Severe or persistent nausea, vomiting, or diarrhea
  • Chest pain
  • A persistent cough
  • Difficulty breathing or shortness of breath
  • Abdominal (stomach) swelling, fullness, or cramping
  • An inability to have a bowel movement
  • Loss of appetite
  • A fast, abnormal, or irregular heartbeat
  • Lightheadedness or fainting
  • Swelling of the arms, legs, ankles, feet, abdomen (stomach), or other areas of the body
  • Unexplained weight loss or weight gain
  • Decreased amount of urine, painful urination, or blood in the urine
  • Frequent urination, blurry vision, or increased thirst
  • Mouth sores
  • Confusion
  • Irregular or missed menstrual periods
  • Seeing or hearing things that are not real (hallucinations)
  • Mood changes, such as depression, agitation, or anxiety
  • Extremely dry skin, eyes, or mouth
  • Yellowing of the skin or whites of the eyes (jaundice)
  • Signs of an allergic reaction, such as:
     
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
 
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Busulfan Injection Information

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