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What Is Bosutinib Used For?

How Does It Work?

Bosutinib belongs to a group of medicines known as tyrosine kinase inhibitors. Tyrosine kinases are proteins found in the body that control cell function, including cell growth.
Bosutinib works by blocking the signal of certain tyrosine kinases, specifically Bcr-Abl tyrosine kinase, which stimulates the development of the abnormal blood cells that cause leukemia. By inhibiting the activity of Bcr-Abl kinase, bosutinib slows down or stops the production of the abnormal blood cells.

Can Children Use It?

Bosutinib is not approved for use in individuals younger than the age of 18, as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using bosutinib in children.

Is It Safe for Older Adults to Use Bosutinib?

Older adults can use bosutinib. In clinical trials, no differences were observed in the way older adults tolerated or responded to bosutinib compared with younger age groups. However, some older adults may be more sensitive to bosutinib side effects and, therefore, may need to be monitored more closely.

What About Off-Label Uses?

On occasion, your healthcare provider may recommend this medication for treating something other than the condition discussed in this article. This is called an "off-label" use. Using bosutinib to treat chronic myelogenous leukemia not associated with the Philadelphia chromosome is an example of an off-label use.
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