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Drug Interactions With Bosutinib

More Detail on Drug Interactions With Bosutinib

The following sections explain in detail the potentially negative reactions that can occur when bosutinib is combined with any of the drugs listed above.
 
Antacids
Stomach acid is needed to absorb bosutinib from the stomach into the bloodstream. Medicines that reduce stomach acid can reduce bosutinib blood levels. You can take bosutinib with antacids -- just make sure to separate the antacid and bosutinib dose by at least two hours.
 
CYP 3A4 Inducer Medications
The liver breaks down bosutinib using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining bosutinib with one of these drugs may decrease the amount of bosutinib in your bloodstream, potentially making it less effective. Bosutinib should not be taken with certain CYP 3A4 inducers. Your healthcare provider can tell you which medicines are safe to take with bosutinib.
 
CYP 3A4 Inhibitor Medications
The liver breaks down bosutinib using enzymes known as CYP 3A4 enzymes, and some medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining bosutinib with one of these drugs may increase the amount of bosutinib in your bloodstream, increasing your risk for serious side effects. Bosutinib should not be taken with certain CYP 3A4 inhibitors. Your healthcare provider can tell you which medicines are safe to take with bosutinib.
 
Digoxin
Bosutinib may increase the level of digoxin in your bloodstream, increasing your risk for digoxin side effects. Your healthcare provider may choose to monitor your digoxin blood levels if you take these medicines together.
 
H2 Blockers
Bosutinib is best absorbed in the presence of stomach acid. Medications that reduce stomach acid, such as H2 blockers, may decrease the amount of bosutinib absorbed from the stomach into the bloodstream. If you take an H2 blocker, make sure to take it at least two hours before, or two hours after, your bosutinib dose.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, including medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove bosutinib from the body. Certain other medications (known as Pgp inhibitors) decrease the activity of Pgp.
 
Taking bosutinib with one of these Pgp inhibitors causes bosutinib to be removed from the body more slowly, increasing bosutinib blood levels and increasing your risk for side effects. Bosutinib should not be taken with certain Pgp inhibitors. Your healthcare provider can tell you which medicines are safe to take with bosutinib.
 
Proton Pump Inhibitors (PPIs)
Stomach acid is needed to absorb bosutinib from the stomach into the bloodstream. Medicines that reduce stomach acid, such as PPIs, can reduce bosutinib blood levels. Do not take bosutinib with a PPI.
 
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Bosutinib Drug Information

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