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Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Heart problems
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Bosutinib to learn more, including information on who should not take the drug.)

How Does It Work?

Bosutinib belongs to a group of medicines known as tyrosine kinase inhibitors. Tyrosine kinases are proteins found in the body that control cell function, including cell growth.
Bosutinib works by blocking the signal of certain tyrosine kinases, specifically Bcr-Abl tyrosine kinase, which stimulates the development of the abnormal blood cells that cause leukemia. By inhibiting the activity of Bcr-Abl kinase, bosutinib slows down or stops the production of the abnormal blood cells.

Clinical Effects of Bosutinib

Bosutinib was studied in a trial that included people with CML who had previously been treated with another tyrosine kinase inhibitor known as imatinib (Gleevec®). Some people had also been treated with other tyrosine kinase inhibitors after imatinib.
In this study, 34 percent of people given bosutinib had a major cytogenetic response after 24 weeks of treatment. A major cytogenetic response means that at least 65 percent of blood cells are normal. More than half the people (52.8 percent) continued to respond to treatment for at least 18 months. 
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Bosutinib Drug Information

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