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Bosutinib Dosage

Available as tablets, bosutinib is taken once daily to help treat a certain type of leukemia. The recommended bosutinib dosage is usually 500 mg taken once daily with food. However, your healthcare provider may increase or decrease this amount, depending on how you respond to the medication and whether you develop side effects.

An Introduction to Your Dosage of Bosutinib

The dose of bosutinib (Bosulif®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • How you respond to the medication
  • Whether you experience side effects
  • Other medical conditions you may have.
  
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Recommended Bosutinib Dosing Guidelines

The standard recommended dosage of bosutinib for the treatment of chronic myelogenous leukemia (CML) is 500 mg once a day with food. Your healthcare provider may increase the amount to 600 mg once a day if you do not achieve an adequate response after 8 to 12 weeks of treatment.
 
You may need to stop taking bosutinib if you experience potentially serious side effects, such as severe diarrhea, low blood cell counts, or increased liver enzymes. Once your side effects improve, your healthcare provider may restart you at the same dosage or reduce the amount to bosutinib 400 mg a day, or even 300 mg a day. Doses less than 300 mg a day have not been adequately studied in clinical trials.
 
People with liver disease are normally given lower doses. The recommended initial bosutinib dose for people with mild-to-severe liver disease is usually 200 mg once a day. This amount is expected to be equivalent to a 500-mg dose in people without liver disease.
 

General Information on Taking Bosutinib

Some considerations to keep in mind during treatment with bosutinib include the following:
 
  • This medication comes in the form of a tablet. It is usually taken by mouth once a day.
 
  • Bosutinib should be taken with food.
 
  • Do not crush, cut, or chew bosutinib tablets; they must be swallowed whole.
 
  • You should avoid consuming grapefruit or grapefruit juice while taking this medication. This is because grapefruit products may cause too much of the medicine to be absorbed from your stomach into your body.
 
  • Try to take your dose at the same time each day to keep an even level of the drug in your bloodstream.
 
  • Avoid touching or handling bosutinib tablets that are broken or crushed. Only handle whole tablets.
 
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking bosutinib just because you feel better.
 
  • If you are unsure about anything related to your dosage, please talk with your healthcare provider or pharmacist.
 
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