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Side Effects of Bevacizumab

Common Side Effects of Bevacizumab

Bevacizumab has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. Because bevacizumab is designed to be used in combination with chemotherapy, these studies compared chemotherapy plus bevacizumab to chemotherapy alone. Therefore, reported side effects could be due to either bevacizumab or chemotherapy.
 
In these studies, the most common side effects of bevacizumab plus chemotherapy that occurred more frequently than side effects of chemotherapy alone included:
 
  • Scaly, peeling skin -- in up to 84 percent of people
  • High blood pressure (hypertension) -- up to 67 percent
  • Abdominal pain (stomach pain) -- up to 61 percent
  • General weakness -- up to 57 percent
  • Infections -- up to 55 percent
  • Vomiting -- up to 52 percent
  • Upper respiratory tract infection (such as the common cold) -- up to 47 percent
  • Fatigue -- up to 45 percent
  • Loss of appetite -- up to 43 percent.
     
With many of these side effects, most of the cases were likely caused by chemotherapy, not bevacizumab, although the drug may slightly increase the risk of such side effects. Your healthcare provider is the best source for information about the side effects you can expect with your particular combination of medications.
  
(Click Chemotherapy Side Effects for a list of common side effects.)
 
Other common side effects of bevacizumab plus chemotherapy (occurring in 2 to 40 percent of people) included:
 
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