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Axitinib Side Effects

Common Side Effects

Axitinib has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking axitinib were carefully documented and compared to the side effects that occurred in a similar group of people taking a different kidney cancer medication. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other drug.
In these studies, common side effects of axitinib included:
  • Diarrhea -- in up to 55 percent of people
  • High blood pressure (hypertension) -- up to 40 percent
  • Fatigue -- up to 39 percent
  • Decreased appetite -- up to 34 percent
  • Nausea -- up to 32 percent
  • Hoarseness or loss of voice -- up to 31 percent
  • Redness, swelling, and peeling of the skin on the palms of the hands or soles of the feet -- up to 27 percent
  • Weight loss -- up to 25 percent
  • Vomiting -- up to 24 percent
  • Weakness or loss of strength -- up to 21 percent.
Other common side effects, occurring in 2 percent to 20 percent of people, included:
  • Constipation
  • Cough
  • Joint and muscle pain
  • Sores and swelling in the mouth
  • Shortness of breath
  • Abdominal (stomach) pain
  • Headache
  • Arm or leg pain
  • Rash
  • Abnormal amounts of protein in the urine
  • Abnormal or metallic taste in the mouth
  • Dry skin
  • Heartburn or indigestion
  • Itching and redness of the skin
  • Hair loss
  • Dizziness
  • Dehydration
  • Nosebleeds
  • Low red blood cell counts (anemia)
  • Hemorrhoids
  • Ringing in the ears
  • Blood in the urine.
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