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Effects of Aloxi

In studies, Aloxi injection was compared to ondansetron (Zofran®) and dolasetron (Anzemet®) for the prevention of nausea and vomiting. When used before chemotherapy that was fairly likely to cause vomiting, up to 81 percent of people taking Aloxi experienced no vomiting within the first 24 hours, compared to just 69 percent of those taking ondansetron.
Aloxi was not significantly better than dolasetron, however. It was also not significantly better than ondansetron when used for chemotherapy that was extremely likely to cause vomiting.
These studies also looked at "delayed" nausea and vomiting, which occurs after the first 24 hours of chemotherapy. Up to 74 percent of people taking Aloxi injection experienced no vomiting during one to five days after chemotherapy, compared to just 55 percent of those taking ondansetron. Aloxi was also more effective than dolasetron for preventing delayed vomiting.
Studies have also shown that Aloxi injection is effective for preventing nausea and vomiting after surgery. In one study, 44 percent of people who were given Aloxi had no vomiting (and no need for other nausea or vomiting medications) in the first 24 hours after surgery, compared to just 19 percent of people who were not given Aloxi.
Lastly, studies have shown that Aloxi capsules (developed after the injection) are at least as good as the injection form for preventing nausea and vomiting in the first 24 hours after chemotherapy.

When and How to Take It

General considerations for when and how to take Aloxi include the following:
  • The medication comes in injectable and capsule form. The IV form is given by IV (intravenously) about 30 minutes before chemotherapy, while the capsule form is taken by mouth one hour before chemotherapy. For surgery, the IV form is given just before anesthesia is started.
  • Aloxi should not be mixed with other medications in the same IV.
  • For the medication to work properly, it must be taken as prescribed.
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