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Drug Interactions With Aldesleukin

Prior to receiving chemotherapy treatment with aldesleukin, talk to your healthcare provider about any other prescription or nonprescription medications you are taking, as well as any vitamins or herbal supplements. Negative interactions can occur if aldesleukin is combined with certain drugs and other products, including corticosteroids, muscle relaxants, and sleep medicines. Some of these reactions can lead to kidney damage, infections, and other serious complications.

An Overview of Aldesleukin Interactions

Aldesleukin (Proleukin®) can potentially react with a number of other products. Some of the drugs that can lead to interactions with aldesleukin include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin


    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
  • Medications that cause drowsiness, such as:
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Aldesleukin Drug Information

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