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Aldesleukin Side Effects

Common Side Effects

Aldesleukin has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people given the drug were carefully documented. As a result, it was possible to see what reactions occurred and how often they appeared.
 
In these studies, the most common aldesleukin side effects included:
 
  • Low blood pressure (hypotension) -- in up to 71 percent of people
  • Diarrhea -- up to 67 percent
  • Decreased urination -- up to 63 percent
  • Chills -- up to 52 percent
  • Vomiting -- up to 50 percent
  • Shortness of breath -- up to 43 percent
  • Rash -- up to 42 percent
  • High bilirubin levels (which could be a sign of liver damage) -- up to 40 percent
  • Low blood platelets (which could increase the risk for bleeding) -- up to 37 percent
  • Nausea -- up to 35 percent
  • Confusion -- up to 34 percent
  • High blood creatine (which could be a sign of kidney damage) -- up to 33 percent.
 
Other common reactions, occurring in 10 percent to 29 percent of people, included:
 
  • Fever
  • Low red blood cells (anemia)
  • Swelling of the arms, hands, legs, ankles, feet, or other areas of the body
  • General feelings of discomfort
  • Weakness or lack of energy
  • Itching
  • Breathing problems
  • Fast heart rate
  • Increase in certain liver enzymes
  • Drowsiness
  • Mouth sores or inflammation
  • Decreased appetite
  • Peeling, flaking, and redness of the skin
  • Low white blood cells (which could increase the risk for infection)
  • Weight gain
  • Infection
  • General pain
  • Abdominal (stomach) pain
  • Enlarged abdomen (stomach)
  • Low blood levels of magnesium and calcium (found using a blood test)
  • Anxiety
  • Dizziness
  • Cough
  • Runny or stuffy nose.
 
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