Your healthcare provider will determine your Adcetris dosage based on how much you weigh. However, if you develop serious side effects during treatment, you may have to temporarily stop receiving this drug and restart at a lower amount. Adcetris is given as an intravenous injection every three weeks. It is given by a healthcare provider and usually takes about 30 minutes to administer.
An Introduction to Dosing With AdcetrisThe dose of Adcetris™ (brentuximab vedotin) your healthcare provider recommends will vary, based on a number of factors, including:
- Your weight
- How well you tolerate the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Recommended Adcetris DosageThe usual recommended dosage of Adcetris for the treatment of lymphoma is 1.8 mg per kg body weight (about 0.82 mg per lb) every three weeks. The dose for people who weigh over 220 lbs should be calculated based on a weight of 220 lbs, as this is the maximum recommended dosage. Treatment will generally continue until 16 doses have been given, as long as the medicine is working and is not causing serious side effects.
Your healthcare provider may recommend temporarily stopping the medicine if you experience certain Adcetris side effects, such as peripheral neuropathy (numbness, tingling, or burning in the hands or feet from nerve damage) or low white blood cell counts. Once your side effects improve, you may be restarted on a lower dose of 1.2 mg per kg body weight (about 0.54 mg per lb).
Some people may experience a potentially serious reaction, known as an infusion reaction, while receiving their Adcetris dosage. Therefore, you will be closely monitored during the infusion. Your healthcare provider may recommend you take other medicines before receiving your dose to help prevent an infusion reaction from occurring. This premedication may include products such as:
- Acetaminophen (Tylenol® and others)
- An antihistamine, such as diphenhydramine (Benadryl® and others)
- A corticosteroid, such as prednisolone (Orapred®, Pediapred®).