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Drug Interactions With Acetaminophen and Pentazocine

More Detail on Drug Interactions With Acetaminophen and Pentazocine

The following sections explain in detail the potentially negative interactions that can occur when acetaminophen and pentazocine is combined with any of the drugs listed above.
 
Alcohol
Consuming alcohol while using acetaminophen and pentazocine could potentially increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while using this medication.
 
Alvimopan
The manufacturer of alvimopan recommends it not be used in people who have been taking opioid medications, including acetaminophen and pentazocine, for seven or more consecutive days immediately before alvimopan is to be started. This is because opioids can increase the risk for alvimopan side effects. Alvimopan is a medication used in people who have just had bowel surgery.
 
Anticholinergic Medications
Taking acetaminophen and pentazocine in combination with anticholinergic medicines could increase your risk for certain side effects, such as urinary retention (an inability to urinate) and severe constipation. Older adults may be more sensitive to these side effects. If you take these medicines together, talk to your healthcare provider if you experience constipation or problems urinating.
 
Azelastine Nasal Spray
Combining azelastine with narcotic pain medications, such as acetaminophen and pentazocine, may increase your risk for drowsiness and decrease your alertness. Talk with your healthcare provider before using these medications together.
 
Barbiturates
Barbiturates can increase how quickly your body processes acetaminophen (one of the active ingredients in acetaminophen and pentazocine), potentially making it less effective, and increasing the risk for liver damage. This is most important for people who take high doses of acetaminophen on a regular basis. Talk to your healthcare provider about this potential interaction if you take these medicines together.
 
Cholestyramine
Cholestyramine can bind to acetaminophen (one of the active components of acetaminophen and pentazocine) in the stomach and prevent it from being absorbed into your bloodstream. If you take these medicines together, make sure to take cholestyramine at least one hour after taking acetaminophen and pentazocine to help reduce the risk for this interaction.
 
Dasatinib
Taking dasatinib with acetaminophen and pentazocine may increase your risk for liver damage. If you take dasatinib, your healthcare provider may recommend you take less acetaminophen and pentazocine. Talk to your healthcare provider about this potential interaction if you take these medications together. 
 
Imatinib
Taking acetaminophen and pentazocine with imatinib may increase your risk for liver toxicity. This is because acetaminophen and pentazocine contains acetaminophen. It is generally recommended that people who take imatinib limit their acetaminophen use to no more than 1300 mg per day. Talk to your healthcare provider before using acetaminophen and pentazocine if you are receiving imatinib treatment.  
 
Medications That Cause Drowsiness
Acetaminophen and pentazocine can cause significant drowsiness. Taking other medications that cause drowsiness while using acetaminophen and pentazocine may lead to serious side effects, such as extreme sedation, confusion, and serious breathing problems. Check with your healthcare provider before taking acetaminophen and pentazocine with other medications that can cause drowsiness. 
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining acetaminophen and pentazocine with an MAOI may lead to dangerously high blood pressure. Talk to your healthcare provider before using acetaminophen and pentazocine if you have taken an MAOI within the past 14 days.
 
Other Opioids
Acetaminophen and pentazocine may block the effects of other opioid medications, which could make the other opioids less effective or cause withdrawal symptoms. Do not take acetaminophen and pentazocine with other opioids without your healthcare provider's approval.
 
Pegvisomant
Opioid medications, such as acetaminophen and pentazocine, can make pegvisomant less effective. Your healthcare provider may need to increase your pegvisomant dose if you take these medicines together.
 
Probenecid
Probenecid may increase blood levels of acetaminophen (one of the active components of acetaminophen and pentazocine), potentially increasing the risk for liver toxicity. Your healthcare provider may recommend a lower acetaminophen and pentazocine dose if you take these medicines together.
 
Sorafenib
Taking sorafenib with acetaminophen and pentazocine may increase your risk for liver damage. If you take these medicines together, your healthcare provider may recommend a lower acetaminophen and pentazocine dosage.
 
Thiazide Diuretics
If you take acetaminophen and pentazocine with a thiazide diuretic, your blood pressure may decrease too much. Your healthcare provider may choose to monitor you more closely for low blood pressure. Let your healthcare provider know if you experience dizziness or fainting, especially when standing, as this could be a sign of low blood pressure.
 
Certain Tobacco Products
Smoking tobacco products (such as cigarettes) can cause the body to remove acetaminophen and pentazocine faster than usual, potentially making it less effective. Make sure your healthcare provider knows if you smoke tobacco products during acetaminophen and pentazocine treatment.
 
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Acetaminophen and Pentazocine Information

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