Abstral Drug Interactions
CYP 3A4 Inhibitor Medications
The body breaks down Abstral using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining Abstral with one of these drugs may increase the level of Abstral in your body, increasing your risk for serious side effects, including drowsiness, confusion, and difficulty breathing. Your healthcare provider may monitor you more closely for side effects if you take Abstral with a CYP 3A4 inhibitor.
Abstral can increase the risk for desmopressin side effects. Do not take Abstral with desmopressin without first speaking with your healthcare provider.
Grapefruit juice may increase the amount of Abstral in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using this medication.
Medications That Cause Drowsiness
Abstral causes significant drowsiness. Combining it with other medications that cause drowsiness may lead to serious side effects, such as extreme sedation, confusion, and breathing problems. Check with your healthcare provider before taking Abstral with other drugs that may cause drowsiness.
Monoamine Oxidase Inhibitors (MAOIs)
Combining Abstral with an MAOI may cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use Abstral if you have taken an MAOI within the past 14 days.
Combining octreotide with Abstral may increase the pain-relieving effects of Abstral. Your healthcare provider may monitor your pain response if you take these medications together. You might need a lower Abstral dosage.